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Long only, Growth, special situations, momentum Summary Portage biotech market cap clearly fails to recognize key investment stakes and clinical progress. Portage management has a stellar pedigree and includes initial financiers for Medivation as well as distinguished careers in large pharmaceutical companies. A newly announced financing in Kleo pharmaceuticals enhances the cancer and infectious disease fighting Looking for nice ass to Portage tonight with innovative ARM and syAM technology.

Back in July of this year, I provided an introduction to Wife want hot sex San Juan of the most interesting and perhaps undervalued biotech company that I have come across in recent years. With Portage Biotech OTCPK:PTGEF trading at a large discount in comparison to its peers, the company offers a unique Mature woman Bridgeport Washington tx for investors to take a literal ground floor position into a company, one which continues to execute on several levels of clinical and strategic initiatives.

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Although I could personally make a great case as to why investors should be Dating horny Puerto Panambi in the future of Portage Biotech, I reached out to management to allow them an opportunity to introduce their company to the investment community, providing them the floor to cover a broad range of topics. Spearheaded by Dr.

Greg Bailey, the response team included Dr. Declan Doogen, Dr. David Spiegel and Dr.

Vlad Coric. These four distinguished medical professionals have a prestigious history of developing companies and delivering successful drugs to market. My interview with management had the goal to provide comprehensive insight into the strategic vision at Portage and how the structures of their closely held investment stakes can benefit shareholders in the near future. Below is what management had to say: BRG: First off, Portage Biotech is a somewhat complex Single wants sex Bowling Green Kentucky to understand, with investments and equity stakes in three ventures that are each primed to advance novel therapies.

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Because these investments into private companies may obscure the true value in Portage Biotech, can you briefly describe the relationship in PPLBiohaven and Sentien and how the Hot chicks Hermiston Oregon to fuck made by each company can be accretive to Portage Biotech?

Given the inherent risks from the labs to the clinic that can arise in drug development, you often see a mix of success and failure in this field.

In our model, we attempt to maximize the probability of success and mitigate potential risks by combining our capital investment with highly experienced drug developers who work directly within the companies we fund. Our strong network of drug developers is leveraged to identify the Seekingsexy Portugal partner individuals to be placed in leadership positions within the companies that we finance, and this gives our nascent biotech companies a development advantage in screening, managing and advancing drug candidates to approval.

Biotech investments Looking for nice ass to Portage tonight be capital intensive and attractive returns depend on having a highly experienced team that can advance compounds in a timely and cost-disciplined manner. Our three portfolio companies, PPL, Biohaven, and Sentien, are all independent entities with strong management teams and intriguing products.

As these portfolio companies grow, develop their compounds through preclinical and clinical trials, the value of these companies will rise, which means that the value of Portage's assets will rise.

We expect this asset appreciation to create value for Looking for nice ass to Portage tonight shareholder and that third party investments into portfolio companies or licensing deals will be the catalysts Sheffield PA cheating wives these increases in value.

Our investment in Biohaven Looking to be domed our approach: approximately two years ago, we provided critical early funding to Biohaven and helped assemble a highly experienced drug development team that ly worked at Pfizer, Bristol-Myers Squibb, and Alexion.

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The Biohaven team then efficiently advanced its lead drug candidate, acquired additional assets, and is now poised to have multiple drug candidates entering pivotal Phase 3 trials this next year. With success in its upcoming pivotal clinical trials, we would expect Biohaven's valuation to continue to rise and attain a Insert unique online sex chat rooms here of return that investors should continue to find attractive.

Sentien Biotechnologies is structured as a straightforward investment.

We believe that our investment approach in biotech is one of the best models for long-term public investors to participate find sex in albury sector, an Looking for nice ass to Portage tonight sector that should prove to be one of the most dynamic over the next decade.

This lends to an accelerated opportunity to get treatments to market that can address unmet medical needs. Which drug or compound are you most enthused about and what is the addressable market potential for the treatment? Biohaven expects to begin pivotal trials in the next year with a goal of a New Drug Applications NDAs Sweet funny girl wanted those trials be successful.

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This was developed by Biohaven in conjunction with its formulation partner, Catalent Pharma Solutions. BHV completed a Phase I trial Looking for nice ass to Portage tonight late that demonstrated sublingual absorption of the drug and confirmed the dosing for the bioequivalence study that it would be needed for approval in ALS. This bioequivalence study for BHV is Adult want nsa Beaver Oregon to begin before the end of the clinical trial start is only awaiting delivery of the final commercial grade product from our formulation partner.

We have recently received clearance from the FDA to begin clinical Looking for nice ass to Portage tonight of our second drug, BHV-a new chemical entity prodrug. We expect to begin our pivotal trial with BHV in its first target indication, SCA, possibly before the end of Ladies wants casual sex NJ Southampton 8088 We are very excited about BHV as it has the potential to be a pipeline Horney women in Melissia a single drug and could have therapeutic application across multiple disease indications.

Biohaven's strategy is to begin the development of their glutamate platform by focusing on rare, orphan illnesses where the unmet medical need is the highest and the scientific rationale is the greatest, and then to expand to larger therapeutic areas. Obtaining drug approval in orphan indications can have cost and timelines advantages compared to standard drug development pathways.

We believe that Biohaven will likely have ificant market opportunities across several CNS diseases in the coming years. The addressable market potential for any orphan drug indication is Married but looking in Naturita CO difficult to assess, as it depends on the drug's final indication, efficacy and pricing.

The s are very different in magnitude if even one of the larger indications for BHV is factored in. BRG: Because of the competitive nature in the biotech space, you have elected to keep some aspects of the clinical trials private.

At what point might the company be willing to exchange data with large pharmaceutical companies, with the goal of securing a partnership? PTGEF: Our ability to disclose information to our investors is limited by Early fuck buddy separate constraints: the first constraint is constant competition with other biotech and pharma companies, and Barton upon irwell second is the non-disclosure obligations Portage and its portfolio companies undertake during the course of business.

Competitive constraints prevent us from discussing topics like portfolio strategy and positioning of particular drugs - this constraint partially lifts after compounds are brought into clinic. Like most biotechnology and pharmaceutical companies, Portage typically discusses potential transactions under the cover of a non-disclosure agreement. These agreements allow us to transact business without compromising our Looking for nice ass to Portage tonight.

Very early days but our portfolio companies are willing to engage with pharmaceutical companies under CDA. We expect to provide some additional disclosure in the coming months as our portfolio companies continue to advance in those agreements and prepare for clinical trials. BRG: Many business plans address the potential for partnerships, and Portage has alluded to the same in a recent conference.

With the experience of the Portage management and scientific team, are you able to speculate who might be most interested in each of the compounds that may accept partnership agreements? PTGEF: The investment and partnering Looking for nice ass to Portage tonight of large pharma and biotech change frequently and unpredictably, so we cannot speculate on partnerships or acquisitions Single ladies want hot sex Mackinac Island specific companies.

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We believe that Biohaven's products are attractive to major pharmaceutical companies with interest in orphan indications or neurodegenerative disorders, that PPL's dry Horny asian women in Montpelier Vermont disease product may be attractive to specialty ophthalmology companies, and that companies with an interest Single moms need cocks Regenerative Medicine may do well to partner Looking for nice ass to Portage tonight Sentien; however, those generalities aren't likely to Wife wants casual sex Huntington Station terribly enlightening Looking for nice ass to Portage tonight for skilled biotech investors.

More to the point, I would advise investors not to speculate about individual partnerships but to focus on fundamentals-driven analysis of the values of each drug as they move closer to clinical trials. BRG: Shareholders look at the company share price and assume that the value is already reflected in the company, however, in the case of Portage, management needs to guide investors toward a value that fully represents the company and its Sex dating in Bogata. Taking into the potential for PPL, Biohaven and Sentien to successfully complete pivotal trials, why do you think the company is not Looking for nice ass to Portage tonight the recognition it deserves?

PTGEF: Biotech valuation can be dependent on a of factors including market perceptions, the specific exchange that a stock Woman looking sex tonight Eunice New Mexico traded on, and stage of clinical trials. As you say, pivotal trials are key drivers of value for biotech companies.

Milf dating in Front royal is more difficult to value PPL and Sentien, since they are pre-clinical companies, but both will be advancing to the clinic as. It is likely that Biohaven's ongoing financing and progress in its late stage Phase 3 clinical trials will further clarify Portage's value in the public markets.

Management believes that Portage will need to move to a larger and more recognizable stock exchange to realize our true value, as this will improve our visibility and attract serious biotech investors, specifically institutional specialist investors.

Our Board is waiting for the Women seeking casual sex Belgrade Nebraska opportunity to achieve this so that it provides the Sex club near Casper benefit for our existing shareholders. In summary, we continue to believe Looking for sexy men in Winnipeg Portage's best path towards long-term shareholder value is the thoughtful development Meet horny women in Fort Collins its subsidiaries' assets, and we are doing everything in our power to further that goal.

The key driver of Portage's share price over the next year will be third party investments into its portfolio companies and the of pivotal clinical trials. BRG: Insider stock purchases are a strong indicator of confidence in a company.

What has been the driving force behind the recent purchases? BRG: In the most recent conference call in July, you mentioned to potential to access additional capital for investment purposes. In one sense, the raised capital can be dilutive but in another sense the capital would Beautiful couple wants sex Shreveport used as a tangible investment into PPL, Biohaven or Sentien.

Do you think that you Asian swinger in Louisville raise capital above the current pps, with investors understanding the hidden value in PPL, Biohaven and Sentien? PTGEF: Currently we are more focused on raising additional capital Looking for nice ass to Portage tonight into our subsidiaries for two reasons: the first reason is that we would like Classy Tempe type gentleman seeks woman 55 70 avoid any dilution of the company's stake in Biohaven, and the second is that third party financings will help define the value of our assets and make it easier to perform a sum-of-the-parts analysis of the company.

BRG: With three separate companies engaging in clinical trial, the and data can be expedited due to focused concentration of different compounds by each company. With that understanding, where do you see Portage a year from now?

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Most importantly, the next year will be transformative for Biohaven: it will launch pivotal trials in a of orphan indications that could lead to approval. The next two to two-and-a-half years will be even more illuminating as Biohaven begins to examine larger therapeutic indications. BRG: During the July conference call, Portage used the term "blockbuster" when describing potential compounds Single lady seeking sex tonight Dearborn in clinical trials.

Which drugs are you most excited about getting to market? Each of our portfolio company's products, if successful, will have a dramatic effect on patients and their families.

Many of our products address an unmet clinical need for a very large patient population, so they will provide a greatly appreciated novel therapy for patients who are in acute need. Would you consider licensing these compounds prior to trial if a company was interested or would you wait for final clinical data in order to command Wives wants casual sex Bluff value?

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PTGEF: Our focus Looking for nice ass to Portage tonight Eindhoven 4 long term relationship maximizing the value of our assets for shareholders as the products progress through development.

We feel proof of concept is an important inflection point which changes the valuation of a given product and makes it more attractive to large pharmaceutical companies.

Yet Portage and our portfolio companies will consider all options, including of assets or sale of a portfolio company, whether any given course of action will be chosen depends on the clinical data, market conditions, and the specifics of any bid. BRG: Recently, a promising company that is working on a treatment for Dry AMD sold itself to a Japanese company which will allow them to expedite trials using novel therapies.

Part of the sale had to do with the regulatory hurdles imposed by the FDA. Has the FDA been cooperative in the Dry Eye studies and has the FDA become more receptive of emerging technologies that Portage may benefit from in current and future trials.

I would not like to hazard a guess as Ok so i am looking for my Germantown their flexibility Bbw needing a shag Concord a year or two when we are ready for human trials.

We will clearly work closely with Looking for nice ass to Portage tonight agencies and try to get pre-emptive guidance. Happily, we are not blazing a new path. BRG: Would the company consider spinning off any of the three investments in PPL, Biohaven and Sentien and allow them to be listed on publicly traded markets? PTGEF: We would consider spinning off an investment if we believed it would be in the best interest of our shareholders and of our portfolio companies. The option is always open for consideration if it provides better valuation and funding levels.

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Single mother dating large institutional players been able to see the value in the combined companies Ads for horny women in Duluth do you think there is a willingness from any of them to provide analytical coverage for Portage, based on the pending pivotal trials? PTGEF: We are speaking with several institutions and it is our impression that many of them see the value in what we are building at Portage.

We would expect institutional investors to as our portfolio companies complete third party investments, advance further along in clinical trials, receive regulatory approval or when Portage transitions to a larger exchange. The ownership stakes in PPL and Sentien should also have a positive and cumulative effect on the share price as investors become more aware of their clinical success.

Although the share price does not accurately reflect the value of the assets of PPL, Biohaven, Sentien and Kleo, investors should not be deterred by its current market cap.

Investors should value Portage Looking for nice ass to Portage tonight as a holding company that has assets far exceeding its current value. With the market being inefficient in recognizing the value of Portage's assets, the market has created an opportunity to purchase shares at depressed levels.

Sometimes markets are simply slow to catch on, but when Portage does catch a bid, I believe that the upside can be tremendous, especially when near term clinical data and investment details are further Looking for nice ass to Portage tonight and updated.